Coatings
Sustained release coatings function by creating a semi-permeable membrane through which drugs must pass in order to become available for absorption, creating a diffusion-controlled rate of release.  Aquacoat^® ECD is our recommendation for this application because it:

• Allows solvent free coating since it is completely aqueous
  
• Offers the greatest formulation flexibility
• Provides stable and reproducible release rates

Recommended Products:

Aquacoat ECD

Extrusion/Spheronization
Extrusion spheronization offers an attractive alternative to traditional drug-layering on pellets. This highly specialized process results in unique spherical, drug-loaded pellets.  The formulator can achieve higher drug loading with this approach over that possible with layering.  We recommend Avicel^® PH-101 or PH-102 for this application because they produce:

• Reduced spheroid friability
• Prevents overwetting and lessens the process sensitivity
• Improved sphericity of pellets

Recommended Products:
 
Avicel PH 101, PH-102