Avicel PH Introduction
Avicel PH is the original microcrystalline cellulose (NF, Ph.Eur., BP, JP) which enabled large scale conversion to direct compression tablet manufacture in the pharmaceutical industry. This revolutionized the industry and brought new levels of efficiency to commercial tablet production. The pharmaceutical industry continues to benefit from FMC BioPolymer's innovation, as modern Avicel PH grades are now available to boost productivity even further. Large-particle Avicel PH-200 enables production to maximize tablet press speed due to its superior flowability. High density grades (Avicel PH-301 and Avicel PH-302) not only improve flow and production rates, but enable larger batch size due since they occupy less volume in key pieces of production equipment. No matter what your formulation challenge, we have the perfect grade of Avicel for you. Only Avicel PH is backed by FMC BioPolymer's worldwide capabilities in manufacturing, technical service, sales and supply chain. Our quality, service, and reliability are unparalleled in the industry. For all of these reasons, Avicel PH is the standard to which all other pharmaceutical excipients are compared.
Applications
Direct Compression, Dry Granulation, Wet Granulation, Extrusion-Spheronization, Encapsulation
Benefits
Over the years, Avicel PH has earned its place in countless solid dosage formulations, thanks to its proven consistency and ability to perform many functions. It is the excipient of choice for direct compression formulations, lending superior compactibility and carrying capacity to tablets. Avicel PH is self-lubricating and promotes rapid disintegration. These properties also benefit dry granulation processes such as roller compaction or slugging. In addition to acting as an auxiliary binder in wet granulation, Avicel PH helps control the wet mass consistency, reduces screen blockage, and promotes uniform, rapid drying. Avicel PH is an essential extrusion-spheronization aid, contributing plasticity to the wet mass in-process while imparting strength to the finished pellet. When included in capsule formulations, Avicel PH improves flow, facilitates plug formation and aids capsule disintegration.
Direct Compression: Make high bulk density Avicel PH-302 or large particle size Avicel PH-200 your preferred choice for direct compression formulations and reap the benefits of increased productivity. Both grades offer flow improvements over the standard Avicel grades. Avicel PH-200 enables the maximum flow, delivering minimum weight variation and excellent content uniformity. The increased density of Avicel PH-302 imparts fast flow as well as the potential to increase production batch size in existing pharmaceutical processing equipment. If you are with coarse, granular, crystalline, or otherwise difficult to compress materials, consider Avicel PH-105. With its very fine particle size and resultant increase in surface area, this grade offers superior compressibility. Avicel PH-105 is often admixed with standard Avicel PH grades in order to achieve desired flow properties.
Moisture Sensitive Drugs: FMC offers three specialized grades of Avicel PH with a varying moisture content and particle size. Look to Avicel PH-112, Avicel-PH-103, and Avicel PH-113 to help extend shelf-life and improve stability of moisture-sensitive formulations
Wet Granulation: Avicel PH-101 is the logical choice for intragranular incorporation as it ensures faster and more trouble-free processing. Avicel PH promotes rapid, even wetting; speeds drying; reduces screen blockage; minimized case hardening; controls dye migration; and promotes disintegration. Post granulation addition of Avicel PH imparts all of the usual direct compression advantages. Consider high density Avicel PH-301 or PH-302 as well as Avicel PH-102 as additions to the running mix to improve flow and compactibility during compression.
Encapsulation: Look to our high density Avicel PH-301 and PH-302 grades to optimize your capsule filling operations. Enhanced flowability results in improved productivity and lower capsule weight variation. Higher density grades occupy less volume in your capsule formulation, leaving precious room for active ingredients.
Detailed Product Descriptions
PRODUCT SPEC SHEETS AVAILABLE: Avicel PH 101, 102, 103, 105 112, 113,200, 301, 302
MSDS
For a copy of the MSDS, please click here