Hydrophilic polymers may be included in tablets in order to form a viscous, gelling layer which retards water penetration and acts as a barrier to drug release.  Drug release is accomplished by diffusion through and erosion of this barrier.  Zero-order release profiles can be achieved by selection of appropriate polymers and other fillers/ binders.  The use of FMC’s carrageenan and alginate in this application provide:

• Suppression of acid burst seen with basic drugs
• 24-hour release rates
• Release profiles that can be tailored by combining gelling and viscous grades

Recommended Products:

Protanal® LF 240 D, LF 120 M, LF 200 M
Viscarin® GP-209, GP-379