Matrix Tablets
Hydrophilic polymers may be included in tablets in order to form a viscous, gelling layer which retards water penetration and acts as a barrier to drug release.  Drug release is accomplished by diffusion through and erosion of this barrier.  Zero-order release profiles can be achieved by selection of appropriate polymers and other fillers/ binders.  The use of FMC’s carrageenan and alginate in this application provide:
  • Suppression of acid burst seen with basic drugs
  • 24-hour release rates
  • Release profiles that can be tailored by combining gelling and viscous grades
Recommended Products:

PROTANAL® CR 8133
MANUCOL® LKX
PROTANAL® 8223
Viscarin® GP-209, GP-379 
Sustained Release Applications
Useful Application Documents